Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone® K29/32 or K90. Flow properties of...

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Bibliographic Details
Main Authors: Vladi Olga Consiglieri, Samanta Mourão, Mauricio Sampaio, Patricia Granizo, Pedro Garcia, Valeska Martinello, Rodrigo Spricigo, Humberto Gomes Ferraz
Format: Article
Language:English
Published: Universidade de São Paulo 2010-03-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100013