Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein.

Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein.

The identification of HIV-1 envelope glycoprotein (Env) structures that can generate broadly neutralizing antibodies (BNAbs) is pivotal to the development of a successful vaccine against HIV-1 aimed at eliciting effective humoral immune responses. To that end, the production of novel Env structure(s...

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Bibliographic Details
Main Authors: Antu K Dey, Brian Burke, Yide Sun, Klara Sirokman, Avishek Nandi, Karin Hartog, Ying Lian, Anthony R Geonnotti, David Montefiori, Michael Franti, Grégoire Martin, Andrea Carfi, Pascal Kessler, Loïc Martin, Indresh K Srivastava, Susan W Barnett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3265465?pdf=render

Internet

http://europepmc.org/articles/PMC3265465?pdf=render

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