Effect of reactive and non-reactive counterion micelles upon the alkaline degradation of indomethacin

In the present paper, kinetics of alkaline degradation of well known drug, indomethacin (2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid), was studied in presence of excess [NaOH]. The rate of hydrolysis of substrate was independent of the [indomethacin] though it increased linearly...

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Bibliographic Details
Main Authors: Abdullah S. Al-Ayed, Mohd. Sajid Ali, Hamad A. Al-Lohedan, Adel M. Al-Sulaim, Zuheir A. Issa
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Saudi Chemical Society
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610311001165