Over-Expression of Inhibitor of Differentiation 2 Attenuates Post-Infarct Cardiac Fibrosis Through Inhibition of TGF-β1/Smad3/HIF-1α/IL-11 Signaling Pathway

Over-Expression of Inhibitor of Differentiation 2 Attenuates Post-Infarct Cardiac Fibrosis Through Inhibition of TGF-β1/Smad3/HIF-1α/IL-11 Signaling Pathway

Background: Cardiac fibrosis after myocardial infarction mainly causes cardiac diastolic and systolic dysfunction, which results in fatal arrhythmias or even sudden death. Id2, a transcriptional repressor, has been shown to play an important role in the development of fibrosis in various organs, but...

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Bibliographic Details
Main Authors: Lin Yin, Ming-xin Liu, Wei Li, Feng-yuan Wang, Yan-hong Tang, Cong-xin Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
inhibitor of differentiation 2
myocardial infarction
cardiac fibrosis
cell apoptosis
hypoxia induced factor-1 alpha (HIF-1α)
interleukin (IL)-11
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01349/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01349/full

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