The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells

The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells

Abstract Background Glioblastoma multiforme (GBM), due to its location, aggressiveness, heterogeneity and infiltrative growth, is characterized by an exceptionally dismal clinical outcome. The small molecule SI113, recently identified as a SGK1 inhibitor, has proven to be effective in restraining GB...

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Bibliographic Details
Main Authors: Silvia Matteoni, Claudia Abbruzzese, Paola Matarrese, Gabriele De Luca, Anna M. Mileo, Stefania Miccadei, Silvia Schenone, Francesca Musumeci, Tobias L. Haas, Giovanni Sette, Carmine M. Carapella, Rosario Amato, Nicola Perrotti, Michele Signore, Marco G. Paggi
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SI113
Glioblastoma multiforme
RPPA
Autophagy
Quinacrine
Online Access:http://link.springer.com/article/10.1186/s13046-019-1212-1

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http://link.springer.com/article/10.1186/s13046-019-1212-1

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