Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

Summary: Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore considered positive facilitators of trans...

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Bibliographic Details
Main Authors: Andrés Herrero-Ruiz, Pedro Manuel Martínez-García, José Terrón-Bautista, Gonzalo Millán-Zambrano, Jenna Ariel Lieberman, Silvia Jimeno-González, Felipe Cortés-Ledesma
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
DNA supercoiling
DNA topology
DNA topoisomerases
transcription elongation
promoter-proximal pausing
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002916

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http://www.sciencedirect.com/science/article/pii/S2211124721002916

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