Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1‐related genes and impairs DNA double‐strand break recognition

Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1‐related genes and impairs DNA double‐strand break recognition

Mesenchymal stem cells (MSCs) are multilineage adult stem cells with considerable potential for cell‐based regenerative therapies. In vitro expansion changes their epigenetic and cellular properties, with a poorly understood impact on DNA damage response (DDR) and genome stability. We report here re...

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Bibliographic Details
Main Authors: Xuanwen Bao, Jing Wang, Guangming Zhou, Attila Aszodi, Veronika Schönitzer, Harry Scherthan, Michael J. Atkinson, Michael Rosemann
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:FEBS Open Bio
Subjects:
BRCA1
cellular aging
DNA repair
homologous recombination
mesenchymal stem cells
Online Access:https://doi.org/10.1002/2211-5463.12867

Internet

https://doi.org/10.1002/2211-5463.12867

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