Dendritic Cells Generated From Mops condylurus, a Likely Filovirus Reservoir Host, Are Susceptible to and Activated by Zaire Ebolavirus Infection

Dendritic Cells Generated From Mops condylurus, a Likely Filovirus Reservoir Host, Are Susceptible to and Activated by Zaire Ebolavirus Infection

Ebola virus infection of human dendritic cells (DCs) induces atypical adaptive immune responses and thereby exacerbates Ebola virus disease (EVD). Human DCs, infected with Ebola virus aberrantly express low levels of the DC activation markers CD80, CD86, and MHC class II. The T cell responses ensuin...

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Bibliographic Details
Main Authors: Kathryn M. Edenborough, Marcel Bokelmann, Angelika Lander, Emmanuel Couacy-Hymann, Johanna Lechner, Oliver Drechsel, Bernhard Y. Renard, Aleksandar Radonić, Heinz Feldmann, Andreas Kurth, Joseph Prescott
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
Ebola virus (EBOV)
reservoir hosts
dendritic cells
transcriptome
Mops condylurus
filovirus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02414/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02414/full

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