Addition of triple negativity of breast cancer as an indicator for germline mutations in predisposing genes increases sensitivity of clinical selection criteria

Addition of triple negativity of breast cancer as an indicator for germline mutations in predisposing genes increases sensitivity of clinical selection criteria

Abstract Background Breast cancer is the most common cancer in women. 12–15% of all tumors are triple-negative breast cancers (TNBC). So far, TNBC has been mainly associated with mutations in BRCA1. The presence of other predisposing genes seems likely since DNA damage repair is a complex process th...

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Bibliographic Details
Main Authors: Juliane Hoyer, Georgia Vasileiou, Steffen Uebe, Marius Wunderle, Cornelia Kraus, Peter A. Fasching, Christian T. Thiel, Arndt Hartmann, Matthias W. Beckmann, Michael P. Lux, André Reis
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Cancer
Subjects:
Breast cancer
TNBC
Next-generation sequencing
Gene panel
Mutational spectrum
Online Access:http://link.springer.com/article/10.1186/s12885-018-4821-8

Internet

http://link.springer.com/article/10.1186/s12885-018-4821-8

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