Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study

Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study

Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor pr...

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Bibliographic Details
Main Authors: Alfonso Piciocchi, Elena Angela Pia Germinario, Koldo Garcia Etxebarria, Silvia Rossi, Lupe Sanchez-Mete, Barbara Porowska, Vittoria Stigliano, Paolo Trentino, Andrea Oddi, Fabio Accarpio, Gian Luca Grazi, Giovanni Bruno, Massimo Bonucci, Massimo Giambenedetti, Patrizia Spigaglia, Fabrizio Barbanti, Slawomir Owczarek, Ida Luzzi, Elisabetta Delibato, Zaira Maroccia, Lorenza Nisticò, Carla Fiorentini, Mauro D’Amato, Roberta De Angelis, Alessia Fabbri
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Toxins
Subjects:
bacterial protein toxins
colorectal cancer
gut microbiota screening
mucosa adherent bacteria
host–pathogens interaction
polygenic risk score
Online Access:https://www.mdpi.com/2072-6651/13/8/569

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https://www.mdpi.com/2072-6651/13/8/569

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