ADAM17-Mediated Reduction in CD14++CD16+ Monocytes ex vivo and Reduction in Intermediate Monocytes With Immune Paresis in Acute Pancreatitis and Acute Alcoholic Hepatitis

ADAM17-Mediated Reduction in CD14++CD16+ Monocytes ex vivo and Reduction in Intermediate Monocytes With Immune Paresis in Acute Pancreatitis and Acute Alcoholic Hepatitis

Impaired immune responses and increased susceptibility to infection characterize acute inflammatory conditions such as pancreatitis and alcoholic hepatitis and are major causes of morbidity and mortality. However, the mechanisms that drive this apparent immune paresis remain poorly understood. Monoc...

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Bibliographic Details
Main Authors: Kathryn Waller, Charlotte James, Anja de Jong, Laura Blackmore, Yun Ma, Andrew Stagg, David Kelsell, Michael O'Dwyer, Robert Hutchins, William Alazawi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
monocytes
inflammation
ADAM17
infection
acute pancreatitis
acute alcoholic hepatitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01902/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01902/full

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