Late onset deficits in synaptic plasticity in the valproic acid rat model of autism

Valproic acid (VPA) is a frequently used drug in the treatment of epilepsy, bipolar disorders and migraines; however it is also a potent teratogen. Prenatal exposure increases the risk of childhood malformations and can result in cognitive deficits. In rodents in utero exposure to VPA also causes ne...

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Bibliographic Details
Main Authors: Henry Giles Stratten Martin, Olivier eManzoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
age
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00023/full