INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification

INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification

Abstract Objective Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric cancer patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in gastric cancer. We showed that decreased levels of RUNX3 are significan...

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Bibliographic Details
Main Authors: Sung-Hwa Sohn, Bohyun Kim, Hee Jung Sul, Yoo Jin Kim, Hyeong Su Kim, Hongtae Kim, Jong Bok Seo, Youngho Koh, Dae Young Zang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Research Notes
Subjects:
INC280
Gastric cancer
c-MET
RUNX3
Diffuse type
Online Access:http://link.springer.com/article/10.1186/s13104-019-4163-x

Internet

http://link.springer.com/article/10.1186/s13104-019-4163-x

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