Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite

Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite

Carbidopa is used for the treatment of Parkinson’s disease (PD) as an inhibitor of DOPA decarboxylase, and PD patients taking carbidopa have a lower incidence of various tumors, except for breast cancer and melanoma. Recently, it was shown that carbidopa inhibits tryptophan-2,3-dioxygenase...

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Bibliographic Details
Main Authors: Diana Duarte, Filipa Amaro, Isabel Silva, Dany Silva, Paula Fresco, José C. Oliveira, Henrique Reguengo, Jorge Gonçalves, Nuno Vale
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Biomolecules
Subjects:
indole-3-acetonitrile
tryptophan
carbidopa
MCF-7 cell line
A375 cell line
Online Access:https://www.mdpi.com/2218-273X/9/9/409

Internet

https://www.mdpi.com/2218-273X/9/9/409

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