Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Here we provide evidence that RBBP4 modulates temozolomide (TMZ) sensitivity through coordinate regulation of two key DNA repair genes critical for recovery from TMZ-induced DNA damage: methylguanine-DNA-methyltransferase (MGMT) and RAD51. Disruption of RBBP4 enhanced TMZ sensitivity, induced synthe...

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Bibliographic Details
Main Authors: Gaspar J. Kitange, Ann C. Mladek, Mark A. Schroeder, Jenny C. Pokorny, Brett L. Carlson, Yuji Zhang, Asha A. Nair, Jeong-Heon Lee, Huihuang Yan, Paul A. Decker, Zhiguo Zhang, Jann N. Sarkaria
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Subjects:
RBBP4
temozolomide
resistance
MGMT
glioblastoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301668

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http://www.sciencedirect.com/science/article/pii/S2211124716301668

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