Enzymatic analysis of recombinant Japanese encephalitis virus NS2B(H)-NS3pro protease with fluorogenic model peptide substrates.

Enzymatic analysis of recombinant Japanese encephalitis virus NS2B(H)-NS3pro protease with fluorogenic model peptide substrates.

BACKGROUND: Japanese encephalitis virus (JEV), a member of the Flaviviridae family, causes around 68,000 encephalitis cases annually, of which 20-30% are fatal, while 30-50% of the recovered cases develop severe neurological sequelae. Specific antivirals for JEV would be of great importance, particu...

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Bibliographic Details
Main Authors: Muhammad Junaid, Chakard Chalayut, Anna Sehgelmeble Torrejon, Chanan Angsuthanasombat, Iryna Shutava, Maris Lapins, Jarl E S Wikberg, Gerd Katzenmeier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3352935?pdf=render

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http://europepmc.org/articles/PMC3352935?pdf=render

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