Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring

Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring

Placental dysfunction can lead to fetal growth restriction which is associated with perinatal morbidity and mortality. Fetal growth restriction increases the risk of obesity and diabetes later in life. Placental O-GlcNAc transferase (OGT) has been identified as a marker and a mediator of placental i...

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Bibliographic Details
Main Authors: Mackenzie Moore, Nandini Avula, Seokwon Jo, Megan Beetch, Emilyn U. Alejandro
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
beta-cells
fetal programming
glucose homeostasis
islet
metabolism
O-GlcNAcylation
Online Access:https://www.mdpi.com/1422-0067/22/13/6918

Internet

https://www.mdpi.com/1422-0067/22/13/6918

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