Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.

Bibliographic Details
Main Authors: Matthew J. Smith, Elizabeth Ottoni, Noboru Ishiyama, Marilyn Goudreault, André Haman, Claus Meyer, Monika Tucholska, Genevieve Gasmi-Seabrook, Serena Menezes, Rob C. Laister, Mark D. Minden, Rolf Marschalek, Anne-Claude Gingras, Trang Hoang, Mitsuhiko Ikura
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01326-5

Internet

https://doi.org/10.1038/s41467-017-01326-5

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