Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.
Bibliographic Details
Main Authors: |
Matthew J. Smith,
Elizabeth Ottoni,
Noboru Ishiyama,
Marilyn Goudreault,
André Haman,
Claus Meyer,
Monika Tucholska,
Genevieve Gasmi-Seabrook,
Serena Menezes,
Rob C. Laister,
Mark D. Minden,
Rolf Marschalek,
Anne-Claude Gingras,
Trang Hoang,
Mitsuhiko Ikura |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-10-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-017-01326-5
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