Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.

Bibliographic Details
Main Authors:	Matthew J. Smith, Elizabeth Ottoni, Noboru Ishiyama, Marilyn Goudreault, André Haman, Claus Meyer, Monika Tucholska, Genevieve Gasmi-Seabrook, Serena Menezes, Rob C. Laister, Mark D. Minden, Rolf Marschalek, Anne-Claude Gingras, Trang Hoang, Mitsuhiko Ikura
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01326-5

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spelling	doaj-8e1f5d31a64445fb84962ab9b91f057b2021-05-11T07:29:16ZengNature Publishing GroupNature Communications2041-17232017-10-018111310.1038/s41467-017-01326-5Evolution of AF6-RAS association and its implications in mixed-lineage leukemiaMatthew J. Smith0Elizabeth Ottoni1Noboru Ishiyama2Marilyn Goudreault3André Haman4Claus Meyer5Monika Tucholska6Genevieve Gasmi-Seabrook7Serena Menezes8Rob C. Laister9Mark D. Minden10Rolf Marschalek11Anne-Claude Gingras12Trang Hoang13Mitsuhiko Ikura14Institute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalCampbell Family Cancer Research Institute, Princess Margaret Cancer CentreInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute of Pharmaceutical Biology, Goethe-University of FrankfurtLunenfeld-Tanenbaum Research Institute, Mount Sinai HospitalCampbell Family Cancer Research Institute, Princess Margaret Cancer CentreCampbell Family Cancer Research Institute, Princess Margaret Cancer CentreCampbell Family Cancer Research Institute, Princess Margaret Cancer CentreCampbell Family Cancer Research Institute, Princess Margaret Cancer CentreInstitute of Pharmaceutical Biology, Goethe-University of FrankfurtLunenfeld-Tanenbaum Research Institute, Mount Sinai HospitalInstitute for Research in Immunology and Cancer, Université de MontréalCampbell Family Cancer Research Institute, Princess Margaret Cancer CentreSeveral rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.https://doi.org/10.1038/s41467-017-01326-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Matthew J. Smith Elizabeth Ottoni Noboru Ishiyama Marilyn Goudreault André Haman Claus Meyer Monika Tucholska Genevieve Gasmi-Seabrook Serena Menezes Rob C. Laister Mark D. Minden Rolf Marschalek Anne-Claude Gingras Trang Hoang Mitsuhiko Ikura
spellingShingle	Matthew J. Smith Elizabeth Ottoni Noboru Ishiyama Marilyn Goudreault André Haman Claus Meyer Monika Tucholska Genevieve Gasmi-Seabrook Serena Menezes Rob C. Laister Mark D. Minden Rolf Marschalek Anne-Claude Gingras Trang Hoang Mitsuhiko Ikura Evolution of AF6-RAS association and its implications in mixed-lineage leukemia Nature Communications
author_facet	Matthew J. Smith Elizabeth Ottoni Noboru Ishiyama Marilyn Goudreault André Haman Claus Meyer Monika Tucholska Genevieve Gasmi-Seabrook Serena Menezes Rob C. Laister Mark D. Minden Rolf Marschalek Anne-Claude Gingras Trang Hoang Mitsuhiko Ikura
author_sort	Matthew J. Smith
title	Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_short	Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_full	Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_fullStr	Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_full_unstemmed	Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_sort	evolution of af6-ras association and its implications in mixed-lineage leukemia
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.
url	https://doi.org/10.1038/s41467-017-01326-5
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Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

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