Molecular Modeling and Structural Stability of Wild-Type and Mutant CYP51 from Leishmania major: In Vitro and In Silico Analysis of a Laboratory Strain

Molecular Modeling and Structural Stability of Wild-Type and Mutant CYP51 from Leishmania major: In Vitro and In Silico Analysis of a Laboratory Strain

Cutaneous leishmaniasis is a neglected tropical disease and a major public health in the most countries. Leishmania major is the most common cause of cutaneous leishmaniasis. In the Leishmania parasites, sterol 14α-demethylase (CYP51), which is involved in the biosynthesis of sterols, has been ident...

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Bibliographic Details
Main Authors: Masoud Keighobadi, Saeed Emami, Milad Lagzian, Mahdi Fakhar, Alireza Rafiei, Reza Valadan
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
Leishmania major
lanosterol 14α-demethylase
mutation
homology modeling
molecular dynamics
protein stability
Online Access:http://www.mdpi.com/1420-3049/23/3/696

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http://www.mdpi.com/1420-3049/23/3/696

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