Senescence of donor cells impairs fat graft regeneration by suppressing adipogenesis and increasing expression of senescence-associated secretory phenotype factors

Senescence of donor cells impairs fat graft regeneration by suppressing adipogenesis and increasing expression of senescence-associated secretory phenotype factors

Abstract Background Fat grafting has been regarded as a promising approach for regenerative therapy. Given the rapidly aging population, better understanding of the effect of age on fat graft outcomes and the underlying mechanisms is urgently needed. Methods C57/BL6 mice [old (O, 18–20-month-old) an...

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Bibliographic Details
Main Authors: Xihang Chen, Jingwei Feng, Qiang Chang, Feng Lu, Yi Yuan
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Fat grafting
Adipogenesis
Senescence-associated secretory phenotype
Adipose-derived mesenchymal stem cells
Donor age
Online Access:https://doi.org/10.1186/s13287-021-02383-w

Internet

https://doi.org/10.1186/s13287-021-02383-w

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