Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice.

Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice.

OBJECTIVE:Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase. Majority of sepsis-mortality occurs during the late sepsis; no therapies exist to treat late sepsis. In lean mice, we have shown that s...

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Bibliographic Details
Main Authors: Xianfeng Wang, Nancy L Buechler, Ayana Martin, Jonathan Wells, Barbara Yoza, Charles E McCall, Vidula Vachharajani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4976857?pdf=render

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http://europepmc.org/articles/PMC4976857?pdf=render

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