Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine

Abstract Subanesthetic ketamine evokes rapid antidepressant effects in human patients that persist long past ketamine’s chemical half-life of ~2 h. Ketamine’s sustained antidepressant action may be due to modulation of cortical plasticity. We find that ketamine ameliorates depression-like behavior i...

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Bibliographic Details
Main Authors: Steven F. Grieco, Xin Qiao, Kevin G. Johnston, Lujia Chen, Renetta R. Nelson, Cary Lai, Todd C. Holmes, Xiangmin Xu
Format: Article
Published: Nature Publishing Group 2021-02-01
Series:Translational Psychiatry
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