Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

Abstract Background The study was performed to evaluate whether targeted alpha-2-macroglobulin (A2M) variants have a similar or enhanced function at wild-type (wt)-A2M to attenuate cartilage degeneration in vivo. Methods In and ex-vivo experiment, bovine cartilage explants (BCE) were incubated with...

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Bibliographic Details
Main Authors: Yang Zhang, Xiaochun Wei, Shawn Browning, Gaetano Scuderi, Lewis S. Hanna, Lei Wei
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Arthritis Research & Therapy
Subjects:
Targeted designed variants of A2M
PTOA
Rat ACLT OA model
Online Access:http://link.springer.com/article/10.1186/s13075-017-1363-4

Internet

http://link.springer.com/article/10.1186/s13075-017-1363-4

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