The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels

The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels

The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin δ-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19 induces antinociception by activation of CB1, μ an...

Full description

Bibliographic Details
Main Authors: Ana C. N. Freitas, Steve Peigneur, Flávio H. P. Macedo, José E. Menezes-Filho, Paul Millns, Liciane F. Medeiros, Maria A. Arruda, Jader Cruz, Nicholas D. Holliday, Jan Tytgat, Gareth Hathway, Maria E. de Lima
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Toxins
Subjects:
Phoneutria nigriventer
opioid receptor
spider toxin
antinociception
Online Access:http://www.mdpi.com/2072-6651/10/1/43

Internet

http://www.mdpi.com/2072-6651/10/1/43

Similar Items