RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5

The small GTPase Ras-related C3 botulinum toxin substrate 1B (RAC1B) has been shown previously by RNA interference-mediated knockdown (KD) to function as a powerful inhibitor of transforming growth factor (TGF)-β1-induced cell migration and epithelial-mesenchymal transition in epithelial ce...

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Bibliographic Details
Main Authors: Hendrik Ungefroren, Hannah Otterbein, Christian Fiedler, Koichiro Mihara, Morley D. Hollenberg, Frank Gieseler, Hendrik Lehnert, David Witte
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
RAC1B
ALK5
cell migration
pancreatic carcinoma
RNA interference
CRISPR/Cas9
TGF-β
Online Access:https://www.mdpi.com/2072-6694/11/5/691

Internet

https://www.mdpi.com/2072-6694/11/5/691

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