Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter.

Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter.

Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either of two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene in aldosterone producing adenomas. These mutation...

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Bibliographic Details
Main Authors: Tobias Åkerström, Joakim Crona, Alberto Delgado Verdugo, Lee F Starker, Kenko Cupisti, Holger S Willenberg, Wolfram T Knoefel, Wolfgang Saeger, Alfred Feller, Julian Ip, Patsy Soon, Martin Anlauf, Pier F Alesina, Kurt W Schmid, Myriam Decaussin, Pierre Levillain, Bo Wängberg, Jean-Louis Peix, Bruce Robinson, Jan Zedenius, Martin Bäckdahl, Stefano Caramuta, K Alexander Iwen, Johan Botling, Peter Stålberg, Jean-Louis Kraimps, Henning Dralle, Per Hellman, Stan Sidhu, Gunnar Westin, Hendrik Lehnert, Martin K Walz, Göran Åkerström, Tobias Carling, Murim Choi, Richard P Lifton, Peyman Björklund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3407065?pdf=render

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http://europepmc.org/articles/PMC3407065?pdf=render

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