Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity.

Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity.

Efficacy of antitumor vaccination depends to a large extent on antigen targeting to dendritic cells (DCs). Here, we assessed antitumor immunity induced by attenuated coronavirus vectors which exclusively target DCs in vivo and express either lymphocyte- or DC-activating cytokines in combination with...

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Bibliographic Details
Main Authors: Christian Perez-Shibayama, Cristina Gil-Cruz, Monika Nussbacher, Eva Allgäuer, Luisa Cervantes-Barragan, Roland Züst, Burkhard Ludewig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842931?pdf=render

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http://europepmc.org/articles/PMC3842931?pdf=render

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