Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

The prognosis of cancer patients with lymph node (LN) metastasis is worse than those without. Here, the authors report that while histone deacetylase 11 (HDAC11) inhibition suppresses tumor growth within the LN, it also promotes cancer cell migration out of the LN to form distant metastasis, and the...

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Bibliographic Details
Main Authors: Patrick L. Leslie, Yvonne L. Chao, Yi-Hsuan Tsai, Subrata K. Ghosh, Alessandro Porrello, Amanda E. D. Van Swearingen, Emily B. Harrison, Brian C. Cooley, Joel S. Parker, Lisa A. Carey, Chad V. Pecot
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12222-5

Internet

https://doi.org/10.1038/s41467-019-12222-5

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