Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model

Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model

Abstract Background Spironolactone can improve endothelial dysfunction in the setting of heart failure and diabetes models. However, its beneficial effect in the cardiovascular system is not clear in the setting of non-diabetic renal failure. We conducted this study to investigate whether spironolac...

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Bibliographic Details
Main Authors: Chun-Cheng Wang, An-Sheng Lee, Shu-Hui Liu, Kuan-Cheng Chang, Ming-Yi Shen, Chiz-Tzung Chang
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Nephrology
Subjects:
Advanced glycation end products
Spironolactone
Endothelial dysfunction
Online Access:http://link.springer.com/article/10.1186/s12882-019-1534-4

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http://link.springer.com/article/10.1186/s12882-019-1534-4

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