The Dual Role of the GABA<sub>A</sub> Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats

The Dual Role of the GABA<sub>A</sub> Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats

Cognitive and motor impairment in minimal hepatic encephalopathy (MHE) are mediated by neuroinflammation, which is induced by hyperammonemia and peripheral inflammation. GABAergic neurotransmission in the cerebellum is altered in rats with chronic hyperammonemia. The mechanisms by which hyperammonem...

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Bibliographic Details
Main Authors: Michele Malaguarnera, Tiziano Balzano, Mari Carmen Castro, Marta Llansola, Vicente Felipo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
bicuculline
cerebellum
astrocyte activation
microglia phenotype
cytokines
GABA and glutamate transporters
Online Access:https://www.mdpi.com/1422-0067/22/13/6772

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https://www.mdpi.com/1422-0067/22/13/6772

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