Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells

Abstract In the absence of a correlate(s) of protection against human tuberculosis and a validated animal model of the disease, tools to facilitate vaccine development must be identified. We present an optimised ex vivo mycobacterial growth inhibition assay (MGIA) to assess the ability of host cells...

Full description

Bibliographic Details
Main Authors: Hannah Painter, Satria A. Prabowo, Felipe Cia, Lisa Stockdale, Rachel Tanner, Samuel Willcocks, Rajko Reljic, Helen A. Fletcher, Andrea Zelmer
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-60223-y