Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Imbalances in GABA (γ-aminobutyric acid) homoeostasis underlie psychiatric and movement disorders. The ability of the 65 kDa isoform of GAD (glutamic acid decarboxylase), GAD65, to control synaptic GABA levels is influenced through its capacity to auto-inactivate. In contrast,...

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Bibliographic Details
Main Authors: Christopher G. Langendorf, Kellie L. Tuck, Trevor L. G. Key, Gustavo Fenalti, Robert N. Pike, Carlos J. Rosado, Anders S. M. Wong, Ashley M. Buckle, Ruby H. P. Law, James C. Whisstock
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-01-01
Series:Bioscience Reports
Subjects:
auto-inactivation
catalytic loop
chimaera
C-terminal domain
glutamic acid decarboxylase
X-ray crystallography
Online Access:http://www.bioscirep.org/bsr/033/e013/bsr033e013.htm

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http://www.bioscirep.org/bsr/033/e013/bsr033e013.htm

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