Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates
Imbalances in GABA (γ-aminobutyric acid) homoeostasis underlie psychiatric and movement disorders. The ability of the 65 kDa isoform of GAD (glutamic acid decarboxylase), GAD65, to control synaptic GABA levels is influenced through its capacity to auto-inactivate. In contrast,...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Portland Press, Biochemical Society
2013-01-01
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Series: | Bioscience Reports |
Subjects: | |
Online Access: | http://www.bioscirep.org/bsr/033/e013/bsr033e013.htm |