Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates
Imbalances in GABA (γ-aminobutyric acid) homoeostasis underlie psychiatric and movement disorders. The ability of the 65 kDa isoform of GAD (glutamic acid decarboxylase), GAD65, to control synaptic GABA levels is influenced through its capacity to auto-inactivate. In contrast,...
Main Authors: | Christopher G. Langendorf, Kellie L. Tuck, Trevor L. G. Key, Gustavo Fenalti, Robert N. Pike, Carlos J. Rosado, Anders S. M. Wong, Ashley M. Buckle, Ruby H. P. Law, James C. Whisstock |
---|---|
Format: | Article |
Language: | English |
Published: |
Portland Press, Biochemical Society
2013-01-01
|
Series: | Bioscience Reports |
Subjects: | |
Online Access: | http://www.bioscirep.org/bsr/033/e013/bsr033e013.htm |
Similar Items
-
FoxO6 and PGC-1α form a regulatory loop in myogenic cells
by: Shih Ying Chung, et al.
Published: (2013-06-01) -
Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles
by: Ross C. Overman, et al.
Published: (2013-06-01) -
The contribution of N2O3 to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation
by: Ahlam A. Ali, et al.
Published: (2013-03-01) -
Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper
by: Matthew J. Sweet, et al.
Published: (2013-07-01) -
Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling
by: Alexander V. Zhdanov, et al.
Published: (2012-10-01)