Genome-wide mapping and profiling of γH2AX binding hotspots in response to different replication stress inducers

Genome-wide mapping and profiling of γH2AX binding hotspots in response to different replication stress inducers

Abstract Background Replication stress (RS) gives rise to DNA damage that threatens genome stability. RS can originate from different sources that stall replication by diverse mechanisms. However, the mechanism underlying how different types of RS contribute to genome instability is unclear, in part...

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Bibliographic Details
Main Authors: Xinxing Lyu, Megan Chastain, Weihang Chai
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Genomics
Subjects:
γH2AX
Replication stress
Genome stability
Fragile sites
Online Access:http://link.springer.com/article/10.1186/s12864-019-5934-4

Internet

http://link.springer.com/article/10.1186/s12864-019-5934-4

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