Oleanolic Acid Acetate Alleviates Symptoms of Experimental Autoimmune Encephalomyelitis in Mice by Regulating Toll-Like Receptor 2 Signaling

Oleanolic Acid Acetate Alleviates Symptoms of Experimental Autoimmune Encephalomyelitis in Mice by Regulating Toll-Like Receptor 2 Signaling

Toll-like receptor 2 (TLR2) is expressed by several immune cells in the central nervous system and plays an important role in neuroinflammation. TLR2 upregulation has been reported in multiple sclerosis patients and in experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple scler...

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Bibliographic Details
Main Authors: Minju Kim, Soyoung Lee, Hyungjin Lim, Jihye Lee, Ji-Young Park, Hyung-Jun Kwon, In-Chul Lee, Young-Bae Ryu, Jeongtae Kim, Taekyun Shin, Ginnae Ahn, Mun-Chual Rho, Kyungsook Jung
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
multiple sclerosis
experimental autoimmune encephalomyelitis
oleanolic acid acetate
Toll-like receptor 2
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.556391/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.556391/full

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