Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.

Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.

Recent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of medulloblastoma.We crossed mice with constitutive activation of Smoothened, SmoA1, with Pten deficient mice. Both constitutive and conditional Pten def...

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Bibliographic Details
Main Authors: Robert C Castellino, Benjamin G Barwick, Matthew Schniederjan, Meghan C Buss, Oren Becher, Dolores Hambardzumyan, Tobey J Macdonald, Daniel J Brat, Donald L Durden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2877103?pdf=render

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http://europepmc.org/articles/PMC2877103?pdf=render

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