Rapid Turnover of the Cardiac L-Type CaV1.2 Channel by Endocytic Recycling Regulates Its Cell Surface Availability

Rapid Turnover of the Cardiac L-Type CaV1.2 Channel by Endocytic Recycling Regulates Its Cell Surface Availability

Summary: Calcium entry through CaV1.2 L-type calcium channels regulates cardiac contractility. Here, we study the impact of exocytic and post-endocytic trafficking on cell surface channel abundance in cardiomyocytes. Single-molecule localization and confocal microscopy reveal an intracellular CaV1.2...

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Bibliographic Details
Main Authors: Rachel Conrad, Gabriel Stölting, Johnny Hendriks, Giovanna Ruello, Daniel Kortzak, Nadine Jordan, Thomas Gensch, Patricia Hidalgo
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900421830124X

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http://www.sciencedirect.com/science/article/pii/S258900421830124X

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