HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

Abstract The mitochondrial paralog of the Hsp90 chaperone family TRAP1 is often induced in tumors, but the mechanisms controlling its expression, as well as its physiological functions remain poorly understood. Here, we find that TRAP1 is highly expressed in the early stages of Zebrafish development...

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Main Authors: Claudio Laquatra, Carlos Sanchez-Martin, Alberto Dinarello, Giuseppe Cannino, Giovanni Minervini, Elisabetta Moroni, Marco Schiavone, Silvio Tosatto, Francesco Argenton, Giorgio Colombo, Paolo Bernardi, Ionica Masgras, Andrea Rasola
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03716-6

Internet

https://doi.org/10.1038/s41419-021-03716-6

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