Opposing effects of inhibitors of Aurora-A and EGFR in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Opposing effects of inhibitors of Aurora-A and EGFR in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule inhibitors targeting AURKA are effective in some patients as monotherapies or combination therapies. EGFR pro-proliferative signaling activity is...

Full description

Bibliographic Details
Main Authors: Anna S Nikonova, Alexander Y Deneka, Louisa eEckman, Meghan C Kopp, Harvey H Hensley, Brian L Egleston, Erica eGolemis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Oncology
Subjects:
EGFR
src
mouse models
renal cyst
Aurora-A kinase
PKD1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00228/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00228/full

Similar Items