Synthesis and metabolism of leukotrienes in γ-glutamyl transpeptidase deficiency

Synthesis and metabolism of leukotrienes in γ-glutamyl transpeptidase deficiency

Leukotrienes (LTs) are active lipid mediators derived in the 5-lipoxygenase pathway. LTC4, the primary cysteinyl LT, is cleaved by γ-glutamyl transpeptidase (GGT), resulting in LTD4. We studied the synthesis and metabolism of LTs in three patients with GGT deficiency. LTs were analyzed in urine, pla...

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Bibliographic Details
Main Authors: Ertan Mayatepek, Jürgen G. Okun, Thomas Meissner, Birgit Assmann, Judith Hammond, Johannes Zschocke, Wolf-Dieter Lehmann
Format: Article
Language:English
Published: Elsevier 2004-05-01
Series:Journal of Lipid Research
Subjects:
cysteinyl leukotriene
glutathione
5-lipoxygenase pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520318307

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http://www.sciencedirect.com/science/article/pii/S0022227520318307

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