Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures

Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures

Temporal lobe epilepsy (TLE) with hippocampal sclerosis is associated with high extracellular glutamate levels, which could trigger seizures. Down-regulation of glial glutamate transporters GLAST (EAAT1) and GLT-1 (EAAT2) in sclerotic hippocampi may account for such increases. Their distribution was...

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Bibliographic Details
Main Authors: L.P. Bjørnsen, T. Eid, S. Holmseth, N.C. Danbolt, D.D. Spencer, N.C. de Lanerolle
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neurobiology of Disease
Subjects:
Astrocytes
Glutamate
Hippocampus
Temporal lobe epilepsy
MTLE
EAAT
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002439

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http://www.sciencedirect.com/science/article/pii/S0969996106002439

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