The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region

The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region

Response mechanisms to external stress rely on networks of proteins able to activate specific signaling pathways to ensure the maintenance of cell proteostasis. Many of the proteins mediating this kind of response contain intrinsically disordered regions, which lack a defined structure, but still ar...

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Bibliographic Details
Main Authors: Jordi Pujols, Jaime Santos, Irantzu Pallarès, Salvador Ventura
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid
Hsf1
protein aggregation
intrinsically disordered regions
Q/N-rich regions
low complexity
molecular recognition features
Online Access:http://www.mdpi.com/1422-0067/19/5/1384

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http://www.mdpi.com/1422-0067/19/5/1384

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