Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences

Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences

Abstract Background Deep immune receptor sequencing, RepSeq, provides unprecedented opportunities for identifying and studying condition-associated T-cell clonotypes, represented by T-cell receptor (TCR) CDR3 sequences. However, due to the immense diversity of the immune repertoire, identification o...

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Bibliographic Details
Main Authors: Dawit A. Yohannes, Katri Kaukinen, Kalle Kurppa, Päivi Saavalainen, Dario Greco
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Bioinformatics
Subjects:
TCR differential abudance analysis
Celiac disease associated TCR clonotypes
Immune repertoire analysis
TCR repertoire analysis
Immuno-informatics
Antigen-specific TCR identification
Online Access:https://doi.org/10.1186/s12859-021-04087-7

Internet

https://doi.org/10.1186/s12859-021-04087-7

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