Optimal Cleavage and Oxidative Folding of α-Conotoxin TxIB as a Therapeutic Candidate Peptide

Optimal Cleavage and Oxidative Folding of α-Conotoxin TxIB as a Therapeutic Candidate Peptide

Alpha6beta2 nicotinic acetylcholine receptors (nAChRs) are potential therapeutic targets for the treatment of several neuropsychiatric diseases, including addiction and Parkinson’s disease. Alpha-conotoxin (α-CTx) TxIB is a uniquely selective ligand, which blocks α6/α3β2β3 nAChRs only, but does not...

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Bibliographic Details
Main Authors: Dongting Zhangsun, Sulan Luo, Qianqian Wu, Qiuyuan Yang, Furong Zhu, Yong Wu, Xiaosa Wu
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Marine Drugs
Subjects:
α-conotoxin TxIB
oxidative folding
optimization
therapeutic peptides
Online Access:http://www.mdpi.com/1660-3397/11/9/3537

Internet

http://www.mdpi.com/1660-3397/11/9/3537

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