Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo

Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo

Abstract Background Insulin-like growth factors and insulin are important factors promoting cancer growth and metastasis. The molecules act through IGF1 (IGF1R) and insulin (InsR) receptors. Rhambodmyosarcomas (RMS) overproduce IGF2 – a potent ligand for IGF1R and, at the same time, highly express I...

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Bibliographic Details
Main Authors: Maciej Tarnowski, Marta Tkacz, Katarzyna Zgutka, Joanna Bujak, Patrycja Kopytko, Andrzej Pawlik
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Cancer
Subjects:
Rhabdomyosarcoma
IGF1R
Pircropodophyllin
Cancer
Online Access:http://link.springer.com/article/10.1186/s12885-017-3495-y

Internet

http://link.springer.com/article/10.1186/s12885-017-3495-y

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