Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice

Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice

Influenza virus (IV) infections are considered to cause severe diseases of the respiratory tract. Beyond mild symptoms, the infection can lead to respiratory distress syndrome and multiple organ failure. Occurrence of resistant seasonal and pandemic strains against the currently licensed antiviral m...

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Bibliographic Details
Main Authors: Stefanie Deinhardt-Emmer, Laura Jäckel, Clio Häring, Sarah Böttcher, Janine J. Wilden, Brigitte Glück, Regine Heller, Michaela Schmidtke, Mirijam Koch, Bettina Löffler, Stephan Ludwig, Christina Ehrhardt
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomolecules
Subjects:
phosphatidylinositol-3 kinase
signaling
influenza virus
Pictilisib
Online Access:https://www.mdpi.com/2218-273X/11/6/808

Internet

https://www.mdpi.com/2218-273X/11/6/808

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