A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors

A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors

Mutations in transcription factor (TF) genes are frequently observed in tumors, often leading to aberrant transcriptional activity. Unfortunately, TFs are often considered undruggable due to the absence of targetable enzymatic activity. To address this problem, we developed CRAFTT, a computational d...

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Bibliographic Details
Main Authors: Kaitlyn M. Gayvert, Etienne Dardenne, Cynthia Cheung, Mary Regina Boland, Tal Lorberbaum, Jackline Wanjala, Yu Chen, Mark A. Rubin, Nicholas P. Tatonetti, David S. Rickman, Olivier Elemento
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306209

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http://www.sciencedirect.com/science/article/pii/S2211124716306209

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